Bone turnover (remodelling)
Bone turnover is the process of resorption followed by replacement by new bone with little change in shape, and it occurs throughout a person's life. Osteoclasts break down bone (bone resorption), releasing the minerals, resulting in a transfer of calcium from bone fluid to the blood.
What is a normal bone turnover rate?
The relatively low adult cortical bone turnover rate of 2 to 3%/yr is adequate to maintain biomechanical strength of bone. The rate of trabecular bone turnover is higher, more than required for maintenance of mechanical strength, indicating that trabecular bone turnover is more important for mineral metabolism.
What is the rate of bone remodeling?
Every 10 years
Bone remodeling. The adult skeleton is renewed by remodeling every 10 years. Remodeling persists throughout life. It has been estimated that 3–4 million bone remodeling units (BRUs) are initiated each year and that 1 million BRUs are actively engaged in bone turnover at any time [Manolagas, 2000].
How long does it take for bone to turnover?
An area of bone is completely replaced after 3 months. Because bone resorption and bone formation are tightly coupled, a marker from either group usually reflects bone turnover rate. Bone comprises about two-thirds mineral and one-third osteoid, most of which is type 1 collagen.
Is bone turnover the same as bone remodelling?
What is the meaning of tissue Remodelling?
The reorganization or renovation of existing tissues
Definition: The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.