As already mentioned, two principal bone cells actively attend the bone remodelling, that is the osteoblasts and the osteoclasts, and an overview of their regulation and function will be done.
What cells make up a remodeling unit?
There are three key cell types that are responsible for matrix production, maintenance and remodeling: viz. osteoclasts, osteoblasts and osteocytes which perform different homeostatic roles [1–3].
What are the two parts of bone remodeling?
The remodeling cycle consists of three consecutive phases: resorption, during which osteoclasts digest old bone; reversal, when mononuclear cells appear on the bone surface; and formation, when osteoblasts lay down new bone until the resorbed bone is completely replaced.
What are the 2 basic types of cells in your bones?
Bone is composed of four different cell types; osteoblasts, osteocytes, osteoclasts and bone lining cells. Osteoblasts, bone lining cells and osteoclasts are present on bone surfaces and are derived from local mesenchymal cells called progenitor cells.
What 2 factors is bone remodeling a response to?
Introduction. Bone remodeling is the result of two opposite activities, the production of new bone matrix by osteoblasts and the destruction of old bone by osteoclasts.
What is bone remodeling in a healthy person?
The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized.